Biological Large Scale Integration BioLSI-2

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The Kavli Nanoscience Institute

Biological Large Scale Integration BioLSI-2

April 10 - 12, 2006

7:00 A.M. - 5:00 P.M.

Winnett Lounge, California Institute of Technology

This workshop follows on the theme of the first BioLSI workshop held in Aspen, January 2004. BioLSI-2 will be a small "working meeting" focusing on universal challenges that currently confront the research community pursuing large-scale-integration of heterogeneous microfluidic systems and biosensors. BioLSI-2 will be kept small to insure a vibrant and open exchange of ideas. The registration fee for the workshop, including continental breakfasts, box lunches, and coffee breaks for the three days of the event is $250.

Logistics, including travel information (pdf).

Registration is now closed.

Jessica Arlett, Rashid Bashir, Steve Buchsbaum, Thomas Braun, Jason Cleveland, Eric Eisenstadt, Alex Groisman, Joseph Hacia, Carl Hansen, Jim Heath, Jong Wook Hong, Emil Kartalov, Luke Lee, Sebastian Maerkl, Scott Manalis, Richard Mathies, Adrian Ozinsky, Mark Paul, Demetri Psaltis, Steve QuakeMichael RoukesAxel Scherer, Christina Smolke, Tom Soh, Sandra Troian, John Wikswo, Changhuei Yang.

Conference Organizers
Michael Roukes, Caltech
Stephen Quake, Stanford

Special thanks to Caltech's Beckman Institute.

The format will be a series of half-hour presentations over three days that focus on state-of-the-art techniques, applications, and issues. Each presentation will be followed by up to a half hour of discussion. To facilitate lively and constructive interchange after each presentation, a separate moderator will join each speaker to stimulate the post-presentation discussion.

A non-exclusive list of possible topics includes:

  • Microfluidics
    • New polymeric materials for microfluidics
    • Novel integrated actuation methods (e.g. beyond pneumatics)
    • High volume/throughput techniques
    • Techniques for extreme conditions (e.g. high temperatures & pressures, harsh chemistry)
    • Theory and modeling of complex microfluidic systems
    • Integration of complex, multi-step biochemical protocols
  • Surface Chemistry at the Micro- and Nanoscale
    • Microfluidic surface biopassivation & biofunctionalization
    • Micro- and nanosensor biopassivation & biofunctionalization
    • Routes to massively multiplexed biofunctionalization
    • New approaches to high avidity analyte capture (aptamers, click-chemistry, minibodies)
    • Stability/lability of surface chemistry (during storage & under conditions of real applications)
  • Micro- and Nanoscale Biosensors
    • Biophysics of analyte-capture transduction
    • Novel biosensing techniques (novel signal transduction)
    • Performance of sensors under real conditions (e.g. complex mixtures, serum)
    • Metrics for sensing (e.g. dynamic range, sensitivity, selectivity, crosstalk…)
    • Enhancement of analyte capture (e.g. dielectrophoretic or fluidic methods)
    • Sensor array engineering (electrical and chemical sensor crosstalk, multiplex readouts)
  • Heterogeneous Systems Integration
  • Production Challenges
  • Microsystems Bioinformatics
    • Biophysics of stochastic analyte capture
    • Signature detection
    • Protocol for signal analysis (e.g. rejection of false positives)
  • Biological Applications