Molecular Circuitry: Construction and Characterization of Coupled Biomolecular Dynamics

Pat Collier, Caltech

We are interested in understanding and controlling assemblies of dynamically interacting biological molecules, in real time. Our goal is to develop an understanding of how collective effects at the molecular level ultimately result in diverse and coordinated behaviors displayed by signaling pathways and other biochemical reaction networks that are essential to cellular functioning, such as signal amplification. As a means toward achieving this goal, we are fabricating elementary molecular circuitry for the development and characterization of coupled enzyme dynamics driven into nonequilibrium steady states. We are also developing functionalized nanoelectrodes integrated on scanning probes for continuous interrogation and control of biochemical reaction dynamics with single molecule sensitivity.

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